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No certain dose adjustment proposed when tofacitinib coadministered with powerful CYP2C19 inhibitors; reduce tofacitinib dose if coadministered with the two moderate CYP3A4 and potent CYP2C19 inhibitors .If you pass up a dose, just take it the moment you could. If it is nearly time for the following dose, acquire only that dose. Usually do not choo